Search found 225 matches
- Thu Feb 07, 2019 10:02 pm
- Forum: Forum
- Topic: No Bay Area Office
- Replies: 6
- Views: 21353
Re: No Bay Area Office
Mati_Roy, I think your projections are too optimistic. 13,000 patients in the next 40 years? Anyway, the number of patients or members doesn't really seem to correlate with quality of care. I would rather have my case be a sole good one rather than be one of 13,000 poor cases. DetnPx, I don't quite ...
- Wed Jan 16, 2019 10:20 am
- Forum: Forum
- Topic: Response to Aschwin's Future Development article
- Replies: 1
- Views: 8654
Response to Aschwin's Future Development article
Aschwin de Wolf wrote an article that just came out in Long Life Magazine. The title is "Part 4: New Research and Future Development". He devoted the second half of the article to Aldehyde Stabilized Cryopreservation (ASC), which is the protocol that we employ at Oregon Cryonics. I think h...
- Fri Dec 21, 2018 6:36 pm
- Forum: Forum
- Topic: No Bay Area Office
- Replies: 6
- Views: 21353
Re: No Bay Area Office
Also, that office was dependent on one or two very wealthy people coming along to fund it. This does happen, but I now realize that even those kinds of people are not willing to pay the true monthly costs. They tend to be willing to pay for immediate tangible equipment such as an ambulance or a dewa...
- Fri Dec 21, 2018 6:28 pm
- Forum: Forum
- Topic: Forum down
- Replies: 0
- Views: 22858
Forum down
Sorry the forum was down for a few weeks. We reconfigured our wiring and internal IP addresses. This server was the last computer that I got to, and then I didn't realize it still wasn't working for a few more days because our WAN address changed slightly. Anyway, that's a long way of saying we're s...
- Fri Oct 19, 2018 2:42 pm
- Forum: Forum
- Topic: No Bay Area Office
- Replies: 6
- Views: 21353
No Bay Area Office
I have finally abandoned my vision of having a branch office in the Bay Area. I'm getting older (47), and there just simply isn't enough time. I guess the good news is that it will allow me to focus more on my work here in Salem. By not spreading myself too thin, I think I can to a better job here. ...
- Sat Sep 15, 2018 8:59 am
- Forum: Forum
- Topic: ASC vs. O.C. $1K aldehyde bath + molecular brain scan
- Replies: 17
- Views: 45001
Re: ASC vs. O.C. $1K aldehyde bath + molecular brain scan
>who will pay Many possibilities: Children, grandchildren, spouses, friends, social safety net, researchers, entrepreneurs, historians. As technology improves, the cost also comes down, and at some point, the cost could become trivial. >get brain damage from ischemia after a few minutes No, this is ...
- Tue Aug 14, 2018 4:43 pm
- Forum: Forum
- Topic: Why not invite Mike Darwin?
- Replies: 4
- Views: 11714
Re: Why not invite Mike Darwin?
I'm sure he knows about this forum. His posts are entertaining, but I also enjoy my peace and quiet.
- Mon Jul 16, 2018 7:43 am
- Forum: Forum
- Topic: Singularity
- Replies: 2
- Views: 9755
Re: Singularity
Great article was just posted: https://singularityhub.com/2018/07/15/why-most-of-us-fail-to-grasp-coming-exponential-gains-in-ai/#sm.000pvny4r11rndymr3h2ccjdmr2py Summary: An exponential curve has exactly the same shape along the entirety. It always looks like it's going vertical in the future and a...
- Wed Jun 27, 2018 1:06 pm
- Forum: Forum
- Topic: Suggestion/Hospitals/Cryonics Patients in their new own facilities/hospitals in their future
- Replies: 6
- Views: 15350
Re: Suggestion/Hospitals/Cryonics Patients in their new own facilities/hospitals in their future
That page is terrible -- one of the worst pages I've ever read anywhere on any topic.
- Wed Jun 27, 2018 1:05 pm
- Forum: Forum
- Topic: transportation?
- Replies: 3
- Views: 12170
Re: transportation?
You need to live in Salem if you want our services. Transportation is handled by our local vehicles. We largely ignore remote transport issues because that approach would only result in poor quality preservation, so it's about as good as not even bothering to preserve at all. Remote standby and tran...
- Mon Jun 11, 2018 6:17 am
- Forum: Forum
- Topic: ASC vs. O.C. $1K aldehyde bath + molecular brain scan
- Replies: 17
- Views: 45001
Re: ASC vs. O.C. $1K aldehyde bath
If we have nanorobots in 50 years, they might be in the bloodstream. That's somewhat reasonable. But they wouldn't be small enough to leave the bloodstream. That's really complicated and would take another 50 years. If those robots are just operating by feel, then they would not be able to "see...
- Wed Jun 06, 2018 11:09 pm
- Forum: Forum
- Topic: ASC vs. O.C. $1K aldehyde bath + molecular brain scan
- Replies: 17
- Views: 45001
Re: ASC vs. O.C. $1K aldehyde bath
When I say "scan" I mean slicing up the brain into millions of physical slices. Yes, chopping up the brain. I've been trained in radiology. I don't think a non-destructive scan like you envision would ever be possible. The thicker the sample, the blurrier the image. There are limits to phy...
- Tue May 29, 2018 10:51 pm
- Forum: Forum
- Topic: ASC vs. O.C. $1K aldehyde bath + molecular brain scan
- Replies: 17
- Views: 45001
Re: ASC vs. O.C. $1K aldehyde bath
I think molecular-level is overkill, but I'm guessing around 130 years from now, or 2150. While it wouldn't violate any laws of physics, there are a LOT of intermediate engineering stages that I can envision, each taking a number of years to develop. Since the scan would be destructive, I don't thin...
- Fri May 25, 2018 6:43 am
- Forum: Forum
- Topic: ASC vs. O.C. $1K aldehyde bath + molecular brain scan
- Replies: 17
- Views: 45001
Re: ASC vs. O.C. $1K aldehyde bath
Here it is in layman's terms: ASC is pumping aldehyde through the arteries so that it reaches every single cell. This is done immediately, before the cells have time to degrade. The $1K aldehyde bath is when aldehyde is applied from the outside of the brain rather than through the arteries. In this ...
- Fri Apr 13, 2018 8:55 am
- Forum: Forum
- Topic: The Death of Death in Cryonics
- Replies: 4
- Views: 20407
Re: The Death of Death in Cryonics
In fact, I'm not sure the paper ever got it right, even in the context of society 30 years ago. A large portion of the paper is devoted to the strategy of changing the definition of the word "death". But I think it's self-evident that introducing our own jargon would be futile. Not only wo...
- Thu Apr 12, 2018 9:52 am
- Forum: Forum
- Topic: The Death of Death in Cryonics
- Replies: 4
- Views: 20407
The Death of Death in Cryonics
Brian Wowk wrote a well-known article in 1988 called The Death of Death in Cryonics. http://alcor.org/Library/html/deathofdeath.html It's been 30 years, and I have gradually come to disagree with the conclusions. Cryonics is, by all accepted definitions of death, the freezing of dead people. We are ...
- Mon Apr 09, 2018 2:04 pm
- Forum: Forum
- Topic: Higher concentration of cryoprotectant
- Replies: 6
- Views: 14139
Re: Higher concentration of cryoprotectant
It was pointed out that I should have expressed everything as w/v instead of v/v. Yes, of course. So I just went back and revised the website to reflect w/v. And our chosen percentage is now 82% w/v. There might also be room for further improvement. For example, a higher percentage of DMSO and a low...
- Sun Apr 08, 2018 1:59 pm
- Forum: Forum
- Topic: Higher concentration of cryoprotectant
- Replies: 6
- Views: 14139
Re: Higher concentration of cryoprotectant
On the other hand, if no cryoprotectant was used, as in the case of a straight freeze, then we really are talking about an essentially solid state. In a straight freeze situation, -80C is fine for days/weeks. You know, if a quality fixation was performed on your end prior to cryoprotection, then the...
- Sun Apr 08, 2018 1:36 pm
- Forum: Forum
- Topic: Higher concentration of cryoprotectant
- Replies: 6
- Views: 14139
Re: Higher concentration of cryoprotectant
We left the vials at -80C for days, without any change. Any crystals formed either immediately or within about a day. I was really struck by how syrupy the mixtures remained. Shipping at that temperature would be a liquid state, not a solid state.
- Fri Apr 06, 2018 3:01 pm
- Forum: Forum
- Topic: Higher concentration of cryoprotectant
- Replies: 6
- Views: 14139
Re: Higher concentration of cryoprotectant
The simple experiments were done and the results are fascinating. http://www.oregoncryo.com/researchHighConcentrations.html Ethylene glycol, as used in Aledhyde-Stabilized Cryopreservation (ASC), is a poor choice of cryoprotectant because of its narrow safe concentration zone. Our EG/DMSO mixture is...
- Wed Apr 04, 2018 10:41 am
- Forum: Forum
- Topic: Brain Preservation prize for large mammal
- Replies: 1
- Views: 13245
Re: Brain Preservation prize for large mammal
An article was posted stating that Dr. Boyden is distancing himself from Nectome. https://www.technologyreview.com/s/610743/mit-severs-ties-to-company-promoting-fatal-brain-uploading/ He gave two reasons. 1. It's not known whether the biomolecules are being preserved. This is absolute rubbish. You c...
- Sat Mar 17, 2018 12:38 pm
- Forum: Forum
- Topic: The Case for Brain Cryopreservation
- Replies: 2
- Views: 10425
Re: The Case for Brain Cryopreservation
I've changed my position on this topic. A brain that's been fixed well is firm. This makes it very easy to damage with the craniotome. It also makes it difficult to access the cranial nerves and remove it from the irregular cranial cavity. So it's always a bad idea. The only time we do it now is whe...
- Wed Mar 14, 2018 9:51 am
- Forum: Forum
- Topic: Brain Preservation prize for large mammal
- Replies: 1
- Views: 13245
Brain Preservation prize for large mammal
The Brain Preservation Foundation (BPF) has awarded the Large Mammal Brain Preservation Prize to 21CM, Robert McIntyre, and Greg Fahy. http://www.brainpreservation.org/large-mammal-announcement/ There are also a slew of related news articles. For example: https://www.technologyreview.com/s/610456/a-...
- Fri Mar 09, 2018 1:17 pm
- Forum: Forum
- Topic: Tissue cryopreservation with inductive heating
- Replies: 8
- Views: 19031
Re: Tissue cryopreservation with inductive heating
The only verification we can perform is to look at the ultrastructure under an electron microscope. We would only do this on non-patients. I would say it's fairly difficult to get good electron micrographs. So if the quality of the electron micrographs is good and is consistent across broad areas of...
- Mon Mar 05, 2018 2:17 pm
- Forum: Forum
- Topic: Tissue cryopreservation with inductive heating
- Replies: 8
- Views: 19031
Re: Tissue cryopreservation with inductive heating
It's been established for quite some time that memories are stored as changes in molecular structure of synapses. Yes, we're a bit vague on what that actually means, but it is almost certainly fundamentally correct. As we gain further understanding, we will no doubt refine and expand the model. Any ...
- Tue Jan 23, 2018 9:41 am
- Forum: Forum
- Topic: Higher concentration of cryoprotectant
- Replies: 6
- Views: 14139
Higher concentration of cryoprotectant
I've decided it's time to increase the concentration of cryoprotectant that we use. We've been using 65%, but we're going to move closer to 75% or 80%. Higher concentrations have the very important advantage completely preventing all ice formation, regardless of temperature or cooling rate. This wil...
- Wed Jan 17, 2018 10:01 am
- Forum: Forum
- Topic: Aldehyde Stabilized Cryopreservation
- Replies: 9
- Views: 19342
Re: Aldehyde Stabilized Cryopreservation
I see the link above is broken. I've been more focused on developing protocols, and have eased up on trying to explain them to anyone. I just added a short explanation of toxicity to this page: http://www.oregoncryo.com/suspendedAnimation.html If you don't see it at first, hit refresh. Toxicity is w...
- Tue Jan 16, 2018 8:00 pm
- Forum: Forum
- Topic: Dewar lid needs paint
- Replies: 4
- Views: 16859
Re: Dewar lid needs paint
Not quite sure what you're getting at. A can of spray paint would be considered toxic, I suppose.
- Tue Jan 02, 2018 6:31 am
- Forum: Forum
- Topic: Intermediate Temperature Storage
- Replies: 7
- Views: 20803
Re: Intermediate Temperature Storage
I'll have to make a web page to explain the cost comparisons. It's not lower cost after all. When compared to a CI Cryostat, it uses 3x as much LN2 per volume, and when compared to an Alcor Bigfoot, it uses 2x as much LN2. Those larger dewars are more efficient. But, for its size, it's probably abou...
- Mon Dec 18, 2017 6:33 am
- Forum: Forum
- Topic: Intermediate Temperature Storage
- Replies: 7
- Views: 20803
Re: Intermediate Temperature Storage
The LN2 slowly hits a heat exchanger at the top of the space. Some gas gets vented out the top of the unit as this happens. If the heat exchanger gets too cold, it will pause for about 10 minutes to prevent liquid from coming out the heat exchanger and to prevent the exhaust gas from being too cold....