New electron micrographs?
Posted: Fri Jun 21, 2019 1:01 am
As the Electron Micrographs page itself states, it “was an ideal lab setting which has only a limited resemblance to a human case”. I wonder why there is still so limited literature on neuron/synapses state "immediately" after death, but I remember there was an interesting OC case report prior to the update, where at least there were electron micrographs from a human case.
I guess that the OC website goal is to report only the "results with practical interest" from the researches (that’s probably why there were not specific details about the other “Training/Research” entries within the 42 "cases"), and the result from the “interesting” old Case Report #4 was practically poor (the only information available now comes from web.archive.org and reads “Electron micrograph of immersion fixation with no perfusion. Preservation was very poor. Perfusion is a basic requirement.”), but I remember I read of some loss of synapses… I would like to read of similar things in similar/improved (future) researches/micrographs, but I don’t even know how a cryonics facility can have available an electron microscope.
At this moment, I no longer bother to search this topic in some Alcor or CI page. If anything, I’d prefer searching on google from time to time, finding articles like this: Molecular Communication of a Dying Neuron in Stroke (B Puig - 2018).
I can also read of optimistic titles like synaptic repair after ischemic events, draining optimism even with the same page by reading “some studies describe synaptic modification as a part of death signaling”: I’m not a neuroscience expert at all, but looking for updated info in this manner it becomes easy to desire some additional help to brain preservation, e.g. by some "ASC-improving" drugs to add prior or during the aldehyde administration, if articles like the 2015 one on the dehydroascorbic acid are released more often than a new mice brain electron micrograph from a cryonics point of view.
I guess that the OC website goal is to report only the "results with practical interest" from the researches (that’s probably why there were not specific details about the other “Training/Research” entries within the 42 "cases"), and the result from the “interesting” old Case Report #4 was practically poor (the only information available now comes from web.archive.org and reads “Electron micrograph of immersion fixation with no perfusion. Preservation was very poor. Perfusion is a basic requirement.”), but I remember I read of some loss of synapses… I would like to read of similar things in similar/improved (future) researches/micrographs, but I don’t even know how a cryonics facility can have available an electron microscope.
At this moment, I no longer bother to search this topic in some Alcor or CI page. If anything, I’d prefer searching on google from time to time, finding articles like this: Molecular Communication of a Dying Neuron in Stroke (B Puig - 2018).
I can also read of optimistic titles like synaptic repair after ischemic events, draining optimism even with the same page by reading “some studies describe synaptic modification as a part of death signaling”: I’m not a neuroscience expert at all, but looking for updated info in this manner it becomes easy to desire some additional help to brain preservation, e.g. by some "ASC-improving" drugs to add prior or during the aldehyde administration, if articles like the 2015 one on the dehydroascorbic acid are released more often than a new mice brain electron micrograph from a cryonics point of view.