Sparks Brain Preservation

In a fixative case where perfusion is used, formalin acts deep in the brain within seconds to minutes. This is not at all unclear. The other numbers you are throwing out are nothing but a red herring aka logical fallacy. Fixative being present is more than adequate to arrest autolysis. I'm actually...

Hi Jordan, Greg Fahy is not just “some scientist” with an outlier opinion. He is one of the most important cryobiologists alive, and one of the central figures in organ vitrification. When he started his career, many in the scientific community did not believe whole-organ vitrification was even poss...

Hi Jordan, I'm involved in cryonics SST so we don't rely on funeral home personnel to quickly retrieve the patients, we operate with funeral home cooperation which enables us to quickly retrieve the patient. Unfortunately in a hospital de-animation scenario we have to navigate very carefully as alie...

I think there are two separate issues here. First, I don’t think “scientific consensus” can be used that broadly. There is probably a mainstream consensus that aldehyde fixation is excellent for preserving tissue for histology, EM, and connectomics. But there is not a mainstream scientific consensus...

Hi Jordan, thanks for the response. It is misleading to say cryonics involves “six hours of degradation” until glass transition. In a good cryonics case, the patient is being cooled continuously from the start. Metabolism slows dramatically as temperature falls; a common rule of thumb is that bioche...

I think the reason cryonics organizations and researchers have approached this problem differently is that they came at it from the organ-preservation paradigm. The intuition was not irrational: if one could vitrify and recover a rabbit kidney, and other mammalian organs, then perhaps the remaining ...

Hello, this is Carrie Radomski. I am a longtime cryonics activist and have been involved in the field for over 12 years. I have joined SBP as a member, though I am not currently fully funded with SBP. I joined SBP because I support the existence of a lower-cost option for brain preservation. I am pr...

“I answered poorly, so let me try again.” I actually don’t think you did a bad job explaining yourself. I agree that people in radical life extension are much more likely to be interested in biostasis than the general public. That was true for me personally. I heard about Longevity Escape Velocity t...

Hi Jordan, this is very interesting. I suppose Sparks Brain Preservation is approaching this as a research organization, which may force it into the anatomical gift / NADO / AATB framework. There have already been many cryonics cases in Texas and Florida, and my understanding is that the actual case...

As an update, Nectome’s technical approach appears to differ quite a bit from how Sparks approaches perfusion. Mike Darwin has long emphasized that a major source of brain injury in cryonics is not just what happens after legal death, but what happens during the agonal phase of dying. That phase can...