forum.oregoncryo.com

It's impossible to do the computations to unstir a solution if it's been stirred for more than a few seconds. It doesn't matter how much math you throw at it. It's absolutely impossible because the number of unknown variables exponentially explodes. It won't even be possible if you can calculate the...

Because I'm extremely extremely busy. I'll get to it, but it doesn't seem like a priority. The internet worked just fine without it before.

https://wellcome.org/reports/scaling-connectomics https://cms.wellcome.org/sites/default/files/2023-06/Connectomics-scaling-up-connectomics.pdf Scanning the connectome would be a critical step in revival. Good progress is being made, and I just realized that there was a major flaw in my predictions....

For your specific situation, your approach sounds reasonable. It's hard to keep the container from leaking. If shipping by airline, don't leave any air space in the bucket, because that can expand at altitude and cause a leak. Also, airlines have limits on dry ice. If shipping ground or specialty tr...

If we don't store in LN2, then we would at least store in refrigeration so that the lipids were more solid. So I started planning out a huge walk-in refrigerator where we could store many racks of small containers. It then occurred to us that maybe we should make it a walk-in freezer because that mi...

Dr. Toner means well. He just thinks we're attempting suspended animation, but we're not. His confusion is understandable because a lot of prominent cryonicists are really pursuing suspended animation rather then purely structural brain preservation. They even gave the name Suspended Animation to on...

James Arrowood is the new Co-CEO of Alcor. He was interviewed recently in the following podcast: https://www.cryonicsunderground.com/1510453/13388129-james-arrowood-new-leadership-and-new-directions-at-alcor Boy, he's a talker. Nearly 3 hours. I ran it at 2x speed. Here are some things I learned: Al...

Yes, it's definitely time for us to rebrand. We're completely dropping the "cryonics" label and fully adopting the "brain preservation" label. Our new name will be Oregon Brain Preservation. The transition will take a little while. As I said in another thread, the motivation behi...

I've now removed a fair number of brains, so I'm developing some opinions about the procedure. Many of them were research cases rather than patients, and the quality was admittedly not ideal. So after I had removed the first few, I decided firmly that I would not want that done to my brain because o...

Yes, we plan to regularly publish in mainstream science journals. It might be time to rebrand away from "cryonics" right now. While we will always do some cryonics, the majority of our patients are chemically preserved instead. Perhaps the name of the company should reflect that majority. ...

I've always had a little trouble explaining to people why we use fixative and then also cryopreserve. Fixative works very well, so what additional advantage are we getting from the liquid nitrogen? Everyone in the cryonics community has generally agreed that we need cryopreservation, so I've basical...

Our sister company, Apex Neuroscience, is finally up and running. http://apexneuro.org/ Apex does all the research, works out the protocols, and has deep expertise. Oregon Cryonics owns all the equipment and the building. The main advantage of this arrangement is that Apex will be a 501c3, so that i...

How exciting for you! I hope you are able to keep it going.

We already did a rough version of an app that let members apply. They entered info in all the fields and it was stored in our server. It also tracked membership status, payment status, life insurance status, etc. It took a lot of time. And then it was hard to maintain. The server is still sitting th...

On a given subject occasionally most 'scientists' can be wrong most of the time Absolutely not. The scientists are always more right than anyone else could ever be. That's the whole point of the scientific revolution. This is not even up for debate. You used the example of self experimentation on a...

Wow, that's an extreme diet. It seems to lack any controlled studies. Shouldn't we instead follow diets that science has shown to be beneficial? There is strong scientific consensus that a carnivore diet is a bad idea. I don't understand how you can ignore that. It has nothing to do with common wisd...

Most cryonicists I talk to describe cryonics as their backup plan in case life extension doesn't work out. I've alway treated it the other way around, with life extension as my secondary goal. The reason for this is that I've never thought that life extension could happen in my lifetime. Nevertheles...

I should have known that a 10x resolution improvement was too good to be true. I wasn't skeptical enough.

I heard that Alcor gave up on trying to use this model of CT scanner. The quality of the machine and software were just too low to have any usefulness at all. Thank goodness we didn't buy one of those yet. We almost did. I guess we'll stick with medical grade CT scanners. It's frustrating that they ...

About six years ago, Vice Motherboard did a 23 minute documentary that heavily featured Oregon Cryonics. https://www.youtube.com/watch?v=m5KuNAeOtJ0 I've never posted a reply about it, but it's been bugging me lately. Dr. Mehmet Toner was also prominently featured. He seems like a nice reasonable gu...

I disagree with a number of ideas in that recent article. First of all, in non-ideal cases you're not necessarily forced to accept ice crystals. In fact, you can always avoid a straight freeze. The protocol is to submerge in glutaraldehyde and ramp up the cryoprotectant over weeks/months. We do this...

The building has been complete for a number of months. We have already started a remodel to add more lab space on the second floor. I've been working hard since day one to make the organization outlast me. I will be a patient, so that's critical. But if I don't get preserved well, then none of that ...

I got an email from someone suggesting that we fix a brain with aldehyde and then submerge it in resin. It was suggested that this would be more stable and cheap than storage in liquid. Here was my response: Hmm. That ideas has been floated around before, but I don't see much advantage over just kee...

Vaguely, yeah. That's fantastic! I did not see that coming. Next, they need to remove the requirement to have less than 6 months to live. Alzheimer's comes to mind as an example of a disease that doesn't fall under the 6 month limit. It will happen, but it's really unpredictable how long it will tak...

This question comes up a lot, so I added a page to our website.
http://oregoncryo.com/straightfreeze.html
I sure wouldn't want it done to me.

I think you misunderstand the purpose of a drought map. That shows changes compared to normal. But if you instead look at a rainfall map, you will see that Salem gets at least 10 times as much rain as Phoenix, and the surrounding hills get at least 20 times as much. I say "at least" becaus...

Damage occurs first at the very smallest scales. Molecules break, membranes tear, proteins denature, etc. At this point, the tissue still looks great under light microscopy. Then, some cells start to completely fragment, with the little fragments getting stirred. I really don't see how you could eve...

This post seemed so legit except for the porn link at the bottom which I deleted. Although the poster was deleted, the name of the poster remains and they were obviously a spammer. This seems legit because it's a copy of a post from 2015. If this had been a real post, then I would have replied that ...

Head transplants are coming, so I think we'll be fine by comparison.

Many brains in jars have only been preserved with formaldehyde rather than glutaraldehyde. I don't think this distinction has been discussed very much. I've been noticing a significant difference in brains that get thoroughly preserved with glutaraldehyde. They shrink a little bit. They get tough an...