Scaling up Connectomics

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jordansparks
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Posts: 227
Joined: Thu Aug 27, 2015 3:59 pm

Scaling up Connectomics

Post by jordansparks »

https://wellcome.org/reports/scaling-connectomics
https://cms.wellcome.org/sites/default/ ... tomics.pdf
Scanning the connectome would be a critical step in revival. Good progress is being made, and I just realized that there was a major flaw in my predictions. I was assuming that the electron microscope that would eventually be capable of scanning a human brain would be scanning large diameter slices. I now realize that instead of a million slices, we might instead be talking about (tens/hundreds of?) thousands of tiny cubes, each of which then get sliced thin for scanning using conventional technology. This means that the massive expensive electron microscopes that I had been assuming were necessary just aren't. All we're really waiting for is for the AI analysis to improve. This is a very important realization because software can improve very quickly. Since it now seems to just be a software problem, I'm moving up my predicted date a few decades. So I now think we're looking at more like 90 years to revival instead of 110 years. I'm wrong either way, but it's fun to try to increase prediction accuracy.
Mecsrt
Posts: 19
Joined: Thu Jan 06, 2022 9:30 pm

Re: Scaling up Connectomics

Post by Mecsrt »

Hi Jordan,

Some time ago I read about a new type of scan technology
based in x-ray synchrotron CT with very high resolution (subcellular)
in a very big samples (whole organ) and fit very well with your project's philosophy, because the organs need to be
Well preserved.
Link; https://www.nature.com/articles/s41592-021-01317-x

I think your organisation take the step of old Nectome project, and I think is a good idea you try to put in contact with the people who work in this new scanner.
I hope this information can be helpful for you.
Ps. And yes, we need better software for processing the scanned and preserved brains.
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